Heterozygote advantage maintains Rhesus factor blood group 1 polymorphism : Ecological regression and case - control studies
نویسندگان
چکیده
Heterozygote advantage maintains Rhesus factor blood group 1 polymorphism: Ecological regression and case-control studies 2 3 Jaroslav Flegr , Rudolf Hoffmann, Mike Dammann 1 4 5 1 Division of Biology, Faculty of Science, Charles University in Prague, Prague, Czech Republic 6 2 Department of Hematology, Na Homolce Hospital, Prague, Czech Republic 7 8 9 10 * Corresponding author 11 JF E-mail: [email protected] 12 RH E-mail: [email protected] 13 MD E-mail: [email protected] 14 15 16 17
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Heterozygote Advantage Probably Maintains Rhesus Factor Blood Group Polymorphism: Ecological Regression Study
Rhesus factor polymorphism has been an evolutionary enigma since its discovery in 1939. Carriers of the rarer allele should be eliminated by selection against Rhesus positive children born to Rhesus negative mothers. Here I used an ecologic regression study to test the hypothesis that Rhesus factor polymorphism is stabilized by heterozygote advantage. The study was performed in 65 countries for...
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